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Whether these different signaling patterns translate to different outcomes is an open question in peptide pharmacology

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Placidi M, Emidio GD, Virmani A, D'Alfonso A, Artin PG, D'Alessandro AM, et al

Phase I metabolism of dihexa, which was determined using pooled male rat liver microsomes, was found to be very low, with an average intrinsic clearance (Cl int ) of 2.72 l/min/mg and an average half-life of 509.4 minutes