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There are accounts of potential toxicity or side effects that are not yet fully mapped, and some researchers have voiced public concerns with both safety and efficacy

While many people take high doses for long periods, it is often best to use a 1500 mg dose for a specific period (such as 36 months) to reach a goal, and then transition to a lower maintenance dose

Both tirzepatide and retatrutide produce gastrointestinal side effects as their primary adverse reactions, but the frequency, severity, and specific patterns differ between the two compounds

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