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Model performance of efficacy was further assessed by applying the model derived from our self-report data in a sample of 642 people who had provided HealthKit EHR data but had not completed the GLP1 survey, and hence were not used in the construction of the model

(21) regarding the correlation between hyperinsulinemia and hyperandrogenism, to the foundational work by Dunaif and Nestler (19801990) that established the causal relationship between IR and PCOS (23, 24), and through to the debates on the universality of this axis following the formulation of the Rotterdam diagnostic criteria (2003) (25, 26)

However, these studies were not specifically designed to assess bone health as a primary outcome

Durability of weight loss and metabolic adaptation: what happens when the signal is withdrawn