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The comorbidities in epilepsy include depression, anxiety, dementia, stroke, migraine, and heart disease et al

Given the ancient origin of the Ca 2+ -based signaling, which evolutionary developed earlier than the mitochondrial apoptotic toolkit whose emergence cannot be dated back to the times earlier than eukaryogenesis and acquisition of an endosymbiotic mitochondrion, it can be assumed that the Ca 2+ toolkit takes over a key role in cell death signaling in terminally differentiated mitochondria-free erythrocytes

Streptococcus suis is a common porcine pathogen (135)

Moreover, the metabolic reprogramming by intensifying glutamine metabolism can contribute to the development of resistance to cancer treatment (146)