Nonnutritive agonists of sweet taste receptors do increase GLP-1 levels and mice null for one such sweet taste receptor, -gustducin, have reduced GLP-1 responses to an oral glucose load (102)
(PubMed) Khalili M, Soltani M, Moghadam SA, Dehghan P, Azimi A, Abbaszadeh O
Here, in vitro morphological analyses showed clear signs of apoptosis, such membrane blebbing, cell shrinkage, and cleaved caspase-3 positive cells in guarana-treated cells (12.550 mg/mL) after 24 hours of treatment (Figure 2)
Based on its powerful anti-inflammatory and neuroprotective activities, minocycline, a tetracycline antibiotic that can cross the BBB, is a candidate for the treatment of depression and anxiety