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After consideration of the comments received, we are finalizing our proposal to modify the Excessive Radiation Dose or Inadequate Image Quality for Diagnostic Computed Tomography (CT) in Adults (Hospital LevelOutpatient) measure (Excessive Radiation eCQM) from mandatory reporting beginning with the CY 2027 reporting period/CY 2029 payment determination to continue voluntary reporting beginning with the CY 2027 reporting period

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In addition to haemodynamic overload, uraemic toxin accumulation and altered ion homeostasis, which are known to underlie left ventricular hypertrophy in CKD and drive cardiac dysfunction, we examine the role of myocardial metabolic remodelling in CKD

The phase 2 trial published in the New England Journal of Medicine documented heart rate increases across every dose group