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A cross-sectional study using 20132018 National Health and Nutrition Examination Survey data revealed that low serum uric acid levels in adults were significantly associated with the risk of epilepsy and may be an independent risk factor for epilepsy ( 4 Epilepsy and metabolic diseases 4.1 Epilepsy and diabetes mellitus 4.1.1 Epilepsy and diabetes mellitus correlation In a retrospective study of 229 adults with type 1 diabetes mellitus (T1DM) in Spain, the prevalence of epilepsy was 2/229 (0.8%) ( In a 10-year follow-up study of 751,792 type 2 diabetes mellitus (T2DM) patients in Taiwan, the incidence of epilepsy was higher in T2DM patients than in controls (35.0 and 21.9 per 10,000 person-years, respectively), and T2DM increased the risk of epilepsy by approximately 50% ( 4.1.2 Clinical characteristics of patients with epilepsy complicated with diabetes mellitus Among 2016 patients with DRE, 20 patients with T1DM had focal epilepsy, with most seizures originating in the temporal lobe