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The declining levels of IGF-1 in GF mice are associated with retarded linear growth, reduced body weight, and impaired bone formationincluding shorter femur length, lower cortical bone density, and reduced trabecular bone densityall of which indicate that GM plays an important role in optimizing growth

Fasano, A., Fiorentini, C., Donelli, G., Uzzau, S., Kaper, J

189 Both forms of the enzyme catalyze the cleavage of dipeptides from the N-terminus of peptide substrates that contain on average 30-amino-acid residues and that have a proline or alanine residue in the penultimate position

Clinical research has extended this concept by evaluating cagrilintide-semaglutide treatment in adults with overweight or obesity and type 2 diabetes, providing evidence that combined pathway engagement can improve both weight-related and glycemic outcomes [6]