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This fact was associated by the authors with a significant decrease in GSH activity whose main role in the saliva is to maintain the disulfide groups of proteins in a reduced state, which determines their biological activity

If you assume that the 2017 animal study accurately predicts the greater absorption rate in humans, then a 250mg dose of LIPO Berberine might be equivalent to something like 2,500mg of traditionally formulated berberine HCl, which is a high dose

European J Med Chem 11:116359 Nixon RA, Rubinsztein DC (2024) Mechanisms of autophagylysosome dysfunction in neurodegenerative diseases