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doi: 10.1111/pcn.13016 98 MorroniF.TarozziA.SitaG.BolondiC.Zolezzi MoragaJ

However, another study using the CLP mouse model found that administering choline before and after sepsis initiation reduced serum inflammatory mediators such as TNF- and HMGB1, and improved survival via the 7nAChR-dependent mechanism (250, 251)

Studies in the model organism Caenorhabditis elegans have demonstrated that different FOXO isoformsparticularly DAF-16Aexert a significant influence on lifespan extension by activating or repressing specific genes such as gst-20 and srr-4, which either promote or inhibit longevity-associated mechanisms

Humans produce glutathione (called GSH) naturally, but less as we age