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According to the MHRA-approved Summary of Product Characteristics, the most frequently reported side effects include nausea (affecting approximately 40% of patients), vomiting, diarrhoea, constipation, dyspepsia (indigestion), and abdominal pain

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Anyone researching retatrutide should factor this into their risk assessment alongside the standard peptide safety considerations

Subsequent studies have primarily investigated GIP receptor signaling using GIP(1-42) in endogenous receptor expressing cell lines or primary models