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15% intra-study CV and 1 mL), generate enough horsepower to reproduce phase 1 and 2 metabolism (particularly important because one of the reasons standard animal and in vitro models have proven to be poor predictors is due to their non-human metabolic profiles) and to increase assay sensitivity so more sophisticated clinical chemistry outputs of liver function, such as ALT/AST concentrations, can also be detected

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Overproduction of ROS One hallmark feature of IBD is the overproduction of ROS, which causes dysregulation of signal transduction, an inflammatory response, and DNA damage, all of which contribute to the progression and deterioration of the disease (27)