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While there is no definitively established direct mechanism by which GLP-1 receptor agonists cause fatigue, several biological pathways warrant consideration

The optimized semaglutide-loaded DPI, composed of semaglutide, mannitol, coarse lactose, fine lactose, and magnesium stearate at a weight ratio of 0.71:2.0:2.203:0.55:0.037, achieved a fine particle mass (FPM) of 36.9% of the total semaglutide, representing the fraction of particles with an aerodynamic diameter smaller than 5 m suitable for deep lung deposition

While still highly effective, it falls short of the results seen with tirzepatide