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Hence, early diagnosis is critical for the effective management (Janardhanan et al

Our structural analysis indicates that, binding to the regulatory sites in proximity of the antenna region, NADH acts as a positive allosteric modulator by enhancing both the affinity of the inhibitor GTP binding and inhibition of GDH catalytic activity

This is particularly noteworthy, as muscle strength has been reported to decline in older adults by up to 3% per year after the age of 60 [39]

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