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In salt-insensitive humans or animals, a high-salt diet may elicit adaptive responses in renal metabolism that prevent the development of hypertension

However, our earlier observations in the same species (unpublished data) did not reveal any significant differences in renal morphology or urinary protein excretion between SHR and WKY rats aged 416 weeks, except after 48 weeks of age when significant decreases in glomerular filtration rate and glomerular necrosis was evident in SHR

When studies show benefits, theyre generally modest in magnitude

TB-500 is treated as an injury-oriented bolus add-on when higher-dose migration signaling is needed