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When SAH accumulates, it inhibits many methyltransferases and can reduce effective methylation even when folate, methionine or SAM are available

PMID 10572976

Avoid exposure to heat sources, direct sunlight and humid environments

Additionally, data from the phase 3 TROPION-Lung01 trial published in the Journal of Clinical Oncology revealed that dato-DXd showed a progression-free survival (PFS) advantage vs docetaxel, at a median of 4.4 months (95% CI, 4.2-5.6) vs 3.7 months (95% CI, 2.9-4.2), respectively (HR, 0.75