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3.3 cGAS-STING signaling participates in the abnormal activation of FLSs FLSs exhibit abnormal activation and proliferation in the synovium of RA patients, serving as primary effector cells responsible for mediating joint destruction and synovitis (62)

As illustrated in Supplementary Figure 2B, also the coupling efficiency deteriorates in the presence of oxidative stress

To evaluate the target-binding capacity of D-CuP, molecular docking simulations were conducted using AutoDock Vina against the functional domains of p53 (DNA-binding domain) and HDAC7 (catalytic deacetylase domain)

Targeting gut microbiota for diabetic nephropathy treatment: probiotics, dietary interventions, and fecal microbiota transplantation