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In addition, due to the ability of metformin to cross the placenta, continued use of metformin for GDM during pregnancy still raises concerns about its safety and potential adverse effects on the fetus

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Raimondi, M

Additionally, in young overweight patients with IR and PCOS, a 12-month regimen of metformin therapy demonstrated a significant reduction in the prevalence of MS and amelioration of liver complications, enhancing insulin sensitivity ( Therefore, metformin has demonstrated efficacy in the management of PCOS in conjunction with MASLD, particularly in overweight and obese females with PCOS and IR