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There is some concern, however, that, while weight loss in obese patients with asthma is associated with improvements in level of lung function and airway responsiveness to inhaled methacholine [61], no significant improvements have been observed in exhaled nitric oxide [62] or other markers of eosinophilic airway inflammation [63]

It is worthy to note that additional analyses, such as sensitivity and non-linear dose-response, were conducted beyond the predefined analyses in PROSPERO registration, due to their significance in strengthening the findings

Sterile water for injection (SWFI) does not contain a preservative, meaning bacterial growth begins immediately upon opening the vial

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