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58 This change was proposed to be caused by the short duration of treatment and inadequate doses of vitamin C and E

Freezing can cause the vitamins (especially riboflavin and perhaps dexpanthenol) to precipitate or the solution to phase-separate

P., Hogart, A

Ongoing waves of SARS-CoV-2 infection sustain the scenario where in the absence of improved vaccines or immunotherapies, clinically vulnerable individuals will still require annual or biannual vaccinations with updated immunogens matched to circulating variants