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This accumulation reflects not only metabolic dysfunction and oxidative stress but also suggests a broader systemic disruption that may contribute to the pathogenesis of various age-related disorders, including central nervous system diseases [59]

Hohnholt MC, Blumrich E-M, Waagepetersen HS, Dringen R (2017) The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes

Between mid-2024 and early 2025, monthly US searches for "GLP-1 patches" surged from near zero to over 57,000, driven entirely by consumer interest in cheaper, easier alternatives to GLP-1 injections