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In addition, under HFD conditions, most SREBP-1c downstream genes contributing to hepatic lipid accumulation were downregulated (Figure 3B)

The hair loss in this case may have a different distribution pattern, concentrated at the temples and crown rather than diffusely across the scalp

This further aggravates kidney structural and functional damage, which in turn, promotes kidney stone recurrence, forming a vicious cycle of repeated stone formation and renal injury