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Description

Semaglutide, a GLP-1 receptor agonist approved by the FDA for type 2 diabetes and chronic weight management, significantly affects appetite and digestion by slowing gastric emptying and reducing hunger signals

The secondary endpoint was the percentage weight loss at M3 compared to baseline

It is important to note that the upregulation of IL-33 observed in some GLP-1 studies does not universally guarantee mucosal defense, as IL-33 can also drive potent Th2 inflammatory responses depending on the tissue context (53)