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Apoptosis and the ensuing growth of cells have been linked to high expression of the pro-apoptotic protein Bax (221)

First-line treatment typically involves: Methotrexate the most commonly prescribed conventional synthetic DMARD Sulfasalazine or hydroxychloroquine alternative or combination options Leflunomide for patients who cannot tolerate methotrexate These medications are usually combined with short-term corticosteroids (such as prednisolone) to provide rapid symptom relief whilst DMARDs take effect, which can take several weeks to months

In a statement issued by University College London, the trials senior investigator, Thomas Foltynie, characterised the negative result as a major disappointment for patients with Parkinsons disease and for the research community