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REDEFINE Trial Headlines Trial REDEFINE 1 Phase 3 Duration 68 weeks Population (N) 3,417 adults with obesity or overweight + 1 comorbidity, without T2D Key Result 20.4% mean weight change vs 3.0% placebo (treatment-policy)

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3 Current treatment approaches for the PDs Traditional approaches, such as pharmacological, non-pharmacological, and surgical, and some emerging treatment techniques, GT, stem cell therapy, neuroprotective agents, and nanomedicine, exist for treating PD (44)

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