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But, she says, for people who struggle with obesity even after attempting to make healthy diet and lifestyle changes, semaglutide might be worth considering, as it can help a patient lose weight and prevent chronic diseases associated with obesity: When you're obese and you have additional chronic diseases associated with obesity, your risk of [further] chronic disease and death goes up markedly. According to Barnard, the potential downsides of semaglutide generally outweigh the benefits

Semaglutide should not be used by people who have a history of pancreatitis

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Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway