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As far as the intracellular Cu(I) discharge pathways are concerned, Cys containing small peptides, such as GSH, or the antioxidant peptide Atox1 may contribute to Cu(I) release from the carrier

IV administration also introduces risks that oral supplementation does not: Contamination or excessive endotoxin exposure Sterility and compounding failures Infusion reactions Venous irritation or infection Dosing errors Additional cost and clinical complexity The FDA has reported adverse events among patients who received injectable compounded glutathione made with an unsuitable dietary ingredient