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Several factors have been identified related to the pathogenesis of ALS: OS, mitochondrial dysfunction, neuroinflammation, excitotoxicity due to an increase in the neurotransmitter glutamate, defect in axonal transmission and in the metabolism of RNA, apoptosis, cytoskeletal abnormalities, disruption of membrane trafficking, endoplasmic reticulum stress, protein misfolding and aggregation (Papadimitriou et al., 2010

Availability of data and materials The RNA-sequencing data has been uploaded to NCBI's Gene Expression Omnibus (GEO) and can be accessed by public ( All data generated or analyzed in this study are included in this article

Moreover, GLP-1RAs were shown to protect neurons and induce beneficial changes in neuroplasticity in laboratory models of several neurological diseases, including PD (74)

Genetic analysis of tumor necrosis factor promoter function in human tumor-infiltrating lymphocytes and other cell lines