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Welch 1 , Saurabh Mishra 1 , Annette Bellar 1 , Mathew Luknis 1 , Vandana Agrawal 1 and Srinivasan Dasarathy 2 , (1)Cleveland Clinic, (2)Cleveland Clinic, Cleveland, OH, United States Background: Sarcopenia (skeletal muscle loss) and physical frailty in liver disease are due to hyperammonemia-induced mitochondrial dysfunction

Abstract Glutathione-mediated biotransformation in the liver is a well-known detoxification process to eliminate small xenobiotics, but its impacts on nanoparticle retention, targeting and clearance are much less understood than liver macrophage uptake, even though both processes are involved in liver detoxification

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