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Clinical vigilance should focus on: Deep vein thrombosis and pulmonary embolism Stroke and ischemic cardiovascular episodes Peripheral vascular complications Periodic monitoring of cardiovascular status is necessary, especially in patients with additional risk factors such as smoking, obesity, or a sedentary lifestyle

Tfrc , Ptger4 , and Il1b may also serve as tirzepatide-specific targets, potentially elucidating its enhanced anti-inflammatory and metabolic regulatory effects

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However, which treatment scheme is to be superior, safer, and more durable, especially under diverse and complex personal situations, rare research is reported