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When compared to those taking topiramate, GLP-1 users were: 48% less likely to start valproate 42% less likely to start calcitonin gene-related peptide (CGRP) monoclonal antibodies 35% less likely to start tricyclic antidepressants 23% less likely to start the class of drugs called gepants However, there was no significant difference between the two groups, and the need to begin taking beta-blockers