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The choroid plexus has been found to express GLP-1 receptors, and treatment with a GLP-1 RA significantly reduces CSF secretion in vitro and intracranial pressure (ICP) in rodents

Second, most studies relied on intention-to-treat populations and may not fully account for attrition bias, as individuals who experience greater rebound may be more likely to drop out from follow-up, potentially underestimating true weight regain

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Tentative approval means the FDA confirmed the generic meets all quality, safety, and efficacy standards, but Apotex cannot sell it yet because Novo Nordisks patents remain active