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Lilly's Kinsale facility, recognised as ISPE's 2024 Overall Facility of the Year, uses a hybrid SPPS/LPPS platform in which SPPS builds pre-assembled peptide fragments of six to fourteen amino acids, and liquid-phase peptide synthesis (LPPS) then couples those fragments together using continuous processing, with parallel fragment production at multiple global supply nodes creating supply chain resilience that purely centralised batch manufacturing cannot provide
Liberati A, Altman DG, Tetzlaff J, et al
those on GLP-1s find that it helps with constipation in particular
In the OASIS 4 trial, 74% of participants taking the Wegovy pill reported GI side effects, compared to 42% on placebo
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