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Emerging research suggests GLP-1s may directly affect the skin by reducing collagen production, accelerating glycation (which stiffens and weakens collagen fibers), and diminishing hydration levels

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therefore, drugs that induce CYP3A may decrease nirmatrelvir and ritonavir plasma concentrations and reduce PAXLOVID therapeutic effect [see Contraindications (4) and Drug Interactions (7.3) Table 2]