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Vessel co-option is defined as a non-angiogenic process whereby tumor cells directly utilize the pre-existing vasculature of the non-malignant tissue as a supply of oxygen and nutrients, resulting in resistance to anti-angiogenic therapy [5]

In this potentially life-threatening disease, the intrinsic factor for the absorption of vitamin B12 in the stomach is completely absent, resulting in a severe long-term vitamin B12 deficiency with consequences for blood formation, neurological disorders and an inflamed tongue

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