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Further analysis revealed that the expression levels of miR-122, a key molecule targeting Nrf2, was reduced and Nrf2/antioxidant response element (ARE) signaling pathway was regulated in liver tissue evidenced by upregulation of transcription factors Nrf2, Nqo-1, and HO-1, and downregulation of transcription factor Kelch-like ECH-associated protein 1 (Keap-1) ( However, not all mushroom polysaccharides show consistently beneficial effects on hyperlipidemic animals

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