glp 1 patents Ozempic, Wegovy and Rybelsus: The behind Novo Nordisk's weight-loss drugs Looming GLP-1 drug patent expirations

From the earliest animal-derived exenatide to the human-derived GLP-1RA liraglutide, GLP-1RA has undergone short-acting, long-acting, weekly preparations and oral preparations, similar to the development of insulin analogs

The downstream pathway of Nrf2, on the other hand, involves inhibitory effects on oxidative stress, inflammation and apoptosis, including but not limited to several important protein molecules, such as HO-1, SOD, MDA, TNF-, ILs, the caspase family of proteins, Bcl-2 and Bax

Reducing fat storage helps to mitigate the risks associated with obesity, such as cardiovascular diseases and metabolic disorders

doi: 10.3389/fimmu.2020.00202 133 WallsJFSubleskiJJPalmieriEMGonzalez-CottoMGardinerCMMcVicarDWet al