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It was only during the clinical trials for FDA approval that researchers and drug designers realized that patients were simultaneously losing weight in some cases, a lot of it

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Pandey S, Mangmool S, Madreiter-Sokolowski CT, Wichaiyo S, Luangmonkong T, Parichatikanond W (2023) Exendin-4 protects against high glucose-induced mitochondrial dysfunction and oxidative stress in SH-SY5Y neuroblastoma cells through GLP-1 receptor/Epac/Akt signaling

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The mechanisms engaged by this peptideantibody conjugate leading to weight loss and metabolic improvement remain unclear

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