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The significant increase in risk is driven primarily by enteric hyperoxaluria, reduced urinary citrate, and lower urine volume. As clinicians continue to monitor outcomes, Wood emphasized that hydration remains one of the simplest and most effective ways for GLP1 users, especially those with a history of stones, to support kidney health.

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STING-deficient mice showed disease progression comparable to wild-type mice, including incidence, arthritis scores, histopathological changes, and other inflammatory parameters such as B220 + cells, CD4 + cells, and IL-6 (68)

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