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Future research and clinical implications Current studies focus on short-term efficacy, but gaps persist regarding the impact on reproductive health, hormonal balance, and bone density over prolonged use

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Guidelines provided by KDIGO similarly recommend SGLT2i for people with an eGFR of 30 ml/min/1.73 m 2 due to the vascular and renal benefit, despite its modest effect on glucose control [2]

Clinical experience shows nausea severity relates more to total food intake and meal composition than injection timing, though some patients report improved tolerance when injecting during lower-appetite hours