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Lab tests are extremely effective in pinpointing specific problems

However, a subgroup of patients may show overlapping problems involving undermethylation, low methylation reserve, oxidative stress and impaired mitochondrial resilience

Real-world data on the long-term effectiveness of the anti-IL17 agent Secukinumab in treating moderate-to-severe HS showed a 56.5% maximal response rate (evaluated in terms of HiSCR and IHS4 reduction of at least 50%) at 6 months and dropout exceeding 40% at 1 year of treatment [235]