In contrast, the beneficial effects of SGLT2 inhibitors on albuminuria and eGFR decline in DKD were demonstrated by EMPA-REG OUTCOME (Wanner et al., 2016), CANagliflozin cardioVascular Assessment Study (CANVAS) (Perkovic et al., 2018), DECLARE-TIMI58 (Mosenzon et al., 2019b), and Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) (Perkovic et al., 2019)
7,8 This is because T2DM impairs cardiac function by decreasing glucose uptake and uncoupling mitochondrial oxidative phosphorylation, leading to myocardial cell damage and irregular cardiac relaxation patterns
BPC-157 targets localized healing at the injury site
You will continue to receive/inject weekly shots, but the dosage will be increased after months 1, 2, and 3