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Its goal is systemic saturation, so local injection is unnecessary and wasteful

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Entinostat (Ent), as a Class I HDAC inhibitor, downregulates pro-fibrotic genes Acta2 and Col1a1, as well as the pro-inflammatory factor LIF, by inhibiting the SRF-FOXM1 transcriptional axis at concentrations of 510 M in vitro , thereby blocking CAF activation and weakening the STAT3 pathway in tumor cells (112)

The method of any one of embodiments 79-142, wherein the therapeutic agent is released from the formulation over a period of at least 7 days