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Other analogues with marked efficacy in preclinical studies, including non-peptide AMYR agonists are under development. Promising Candidates in Development At this point, it is hard to say which, if any, of these candidates will turn out to deliver important clinical advantages

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Avoid strongly alkaline conditions above pH 8 that promote amide hydrolysis, and avoid strongly oxidising conditions that could modify the Trp9 residue despite the Nle4 substitution eliminating the oxidation-sensitive methionine of native -MSH