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PMID: 20179146[PubMed Reference] Malinda KM, Sidhu GS, Mani H, et al

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79 Chronic hyperglycemia activates mTORC1 and reduces mTORC2 activity 157 in islet cells, which leads to the translocation of FOXO1 to nucleus and less nuclear PDX1, resulting in reduced insulin synthesis and secretion and impaired cell mass 80,158 (Fig

Understanding these chemical properties is crucial for researchers who need to control experimental parameters and choose the right compound for their studies