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PubMed, Mellon, J

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Weight loss and improved metabolic health from semaglutide can lead to increased energy, confidence, and hormonal balanceall factors that may enhance sex drive

Activation of mania/hypomania has also been reported in a small proportion of patients with Major Affective Disorder treated with other marketed drugs effective in the treatment of Major Depressive Disorder [see Use in Specific Populations (8.4)]