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Several GLP-1 agonists have FDA approval for other indications that may overlap with BED patient populations: Semaglutide (Wegovy) and liraglutide (Saxenda) are approved for chronic weight management in adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related comorbidity Semaglutide (Ozempic), liraglutide (Victoza), dulaglutide (Trulicity), and tirzepatide (Mounjaro) are approved for type 2 diabetes management Tirzepatide (Zepbound) is approved for chronic weight management When clinicians prescribe GLP-1 agonists for BED, this constitutes off-label use a legal and common practice in medicine when evidence suggests potential benefit and approved treatments are inadequate

Tuning Ag NP size, shape and surface modification for enhanced properties The size, shape, and surface modifications of Ag NPs strongly influence their interactions, stability and effectiveness as antimicrobial and anticancer agents and catalysts [64]

doi: 10.1056/NEJMOA1911303

it directly impacts the nervous system via the microbiota-gut-brain axis