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Genetically predicted glucose-dependent insulinotropic polypeptide (GIP) levels and cardiovascular disease risk are driven by distinct causal variants in the GIPR region

Prevalence is highest in South America and the Middle East (~44%), followed by Asia (27%), Europe (25%), North America (24%), and Africa (14%)

This combination of delayed digestion and drier stool creates the perfect conditions for constipation

The absence of a head-to-head trial means that prescribing decisions will initially be guided by availability, formulary coverage, individual tolerability, and prescriber familiarity rather than definitive comparative efficacy data