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In addition, some putative effects of GLP-1RAs on cognitive and mental health symptoms may not require direct activity in the CNS, but rather be mediated by the actions that these medications express in the periphery across immune, endocrinemetabolic and gutbrain axis mechanisms (Fig

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By incorporating such programs, they may reduce the long-term costs associated with chronic conditions like diabetes and cardiovascular diseases, improve patient adherence and satisfaction, and ultimately enhance overall population health

43,192,440,441 GLP-1RAs and AS AS is characterized by the formation of fibrofatty plaques within arterial walls and is one of the foremost global causes of mortality