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doi: 10.1016/j.fertnstert.2013.03.048 19 WangJWangJZhangH-RShiH-JMaDZhaoH-Xet al

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In women with PCOS, high concentrations of leptin have been reported to inhibit the expression of aromatase mRNA in granulosa cells, while the hyperandrogenic follicular environment in GCs was found to significantly reduce the expression of P450arom, which can convert androgens into estrogen, further increasing the levels of androgens and ultimately promoting follicular atresia (148150)

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Other therapies for low libido during the menopause transition include systemic hormone replacement therapy (HRT)

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